12204 - 12212 (5)ĭiels-Alder chemistry is a well-explored avenue for the synthesis of bioactive materials however, its potential applications have recently expanded following the development of reactions that can be performed in buffered aqueous environments at low temperatures, including fulvene-maleimide cycloadditions. Retro Diels-Alder Fragmentation of Fulvene-Maleimide Bioconjugates for Mass Spectrometric Detection of Biomolecules Stevens, Katherine G.,McFarlane, Lewis O.,Platts, Kirsten,O’Brien-Simpson, Neil,Li, Wenyi,Blencowe, Anton,Trim, Paul J.,Pukala, Tara L. The novel design strategy of UV light-controlled ADCs may provide new perspectives for future research on ADCs and promote the development of photocontrol systems. Furthermore, our research confirmed that the degradation products of unirradiated ADC, Cys-1a, were relatively less toxic, thus potentially reducing the off-target toxicity caused by nonspecific uptake of ADCs. Compared to those of the unirradiated cells, the EC50 values of ADCs increased by up to 50-fold. Upon irradiation with UV light, the ADC rapidly released free cytotoxins and exerted significant cytotoxicity toward drug-resistant tumor cells. Our preliminary work indicated that the ADC exhibited good stability and photocontrollability while maintaining a targeting effect similar to that of the naked antibody. In this study, we designed, for the first time, a novel ultraviolet (UV) light-controlled ADC by carefully integrating the UV-cleavable o-nitro-benzyl structure into the linker. Developing a novel photocontrol-ADC with good stability and photocontrolled release seemed to be an attractive and practical solution. However, off-target toxicity caused by the instability of linkers remains one of the main issues to be resolved. Novel antibody-drug conjugate with UV-controlled cleavage mechanism for cytotoxin release Li, Jiaguo,Xiao, Dian,Xie, Fei,Li, Wei,Zhao, Lei,Sun, Wei,Yang, Xiaohong,Zhou, Xinbo, (5)Īntibody-drug conjugates (ADCs) are being developed worldwide with the potential to revolutionize current cancer treatment strategies. Manufacture/Brand: American Custom Chemicals Corporationĭescription: 4-BUTYRIC ACID 95.00%ĭescription: 4-(4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy)butanoicacid 95+%.Thermal hazardsĭescription: 4-(4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy)butanoicacid 95%ĭescription: 4-(4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy)butanoicacid Respiratory protection Wear dust mask when handling large quantities. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Skin protection Wear impervious clothing. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Eye/face protection Safety glasses with side-shields conforming to EN166. Wash hands before breaks and at the end of workday. Exposure controls/personal protection: Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice.Keep container tightly closed in a dry and well-ventilated place. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. Handling and storage: Avoid contact with skin and eyes.Keep in suitable, closed containers for disposal. Discharge into the environment must be avoided. Prevent further leakage or spillage if safe to do so. Accidental release measures: Use personal protective equipment.Wear self-contained breathing apparatus for firefighting if necessary. Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.If swallowed Never give anything by mouth to an unconscious person. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. In case of skin contact Wash off with soap and plenty of water. If not breathing, give artificial respiration. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. First-aid measures: General adviceConsult a physician.Hazard Statement: H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation.
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